“Statin users switch to anaerobic metabolism sooner during maximal exercise performance, are more prone to muscle fatigability during repeated muscle contractions, and have a reduced mitochondrial oxidative capacity of the muscle than nonstatin users”

[ctct form=”741″]Evidence for Disturbances in Energy Metabolism

Neeltje A. E. Allard; Tom J. J. Schirris; Rebecca J. Verheggen; Frans G. M. Russel; Richard J. Rodenburg; Jan A. M. Smeitink; Paul D. Thompson; Maria T. E. Hopman; Silvie Timmers J Clin Endocrinol Metab. 2018;103(1):75-84.

Ok, now, stratify risk increase by level of lost exercise compared to same individuals benefit of taking a statin – any of the Emergency Medicine Sports Med interested folks want to ask for subject level data and knock out a quick quantitative model?

full paper here

medscape summary here




Author: Jason Wilson, MD, PhD, CPE, FACEP

Jason Wilson, MD, PhD, CPE, FACEP is an emergency physician, academic healthcare leader and medical anthropologist with an interest in developing patient-centered pathways that are medically efficacious but also consider the role of structural and cultural forces in determining health inequities and disparities.